The number of canine leptospirosis cases has risen dramatically in recent years, impacting urban and rural dogs. Leptospirosis is a potentially life-threatening disease, and is now the number one infectious cause of acute renal failure in dogs. Leptospirosis may pose a zoonotic (transmissible) risk to owners. All vaccines are shipped overnight. A .95 flat rate fee is charged for all orders containing vaccines. Someone should be present to sign for and receive the vaccine order when it ships to you. For more shipping info click here.